What is it about?
Retinitis pigmentosa (RP) represents a group of hereditary retinal degenerations principally characterized by progressive rod-dominant photoreceptor degeneration in the initial stage and eventual cone photoreceptor degeneration in later stages. RP has been known to be initiated by photoreceptor apoptosis as a final common pathway at the cellular level, irrespective of gene mutations, and apoptosis can thus be considered as a therapeutic target.
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Why is it important?
Retinitis pigmentosa represents a group of hereditary retinal degenerations principally characterized by progressive rod-dominant photoreceptor degeneration in the initial stage and eventual cone photoreceptor degeneration in later stages. Patients with retinitis pigmentosa (RP) mainly complain of night blindness and photophobia in the early stage, followed by gradual constriction of the visual field, decreased visual acuity, and color blindness in later stages. The prevalence of RP is roughly 1 in 4,000-5,000 people, and the condition is common in both Asian and Western countries.
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This page is a summary of: Apoptosis: Current therapeutic approach in retinitis pigmentosa, Journal of Physiology and Pathophysiology, May 2012, Academic Journals,
DOI: 10.5897/jpap11.015.
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