What is it about?
Breast cancer is the most common cancer in women. The most important factor in determining the prognosis and treatment of invasive breast cancer is axillary lymph nodes involvement. It is possible not to detect micro metastasis with applying staining tissues by the Hematoxylin and Eosin (H & E) staining method. Therefore, this study was conducted to determine and compare the detection of axillary lymph node micro metastasis in breast cancer byH& E and immunohistochemical (IHC) method.
Featured Image
Why is it important?
According to the results, IHC is more beneficial than the H&E method to detect micrometastatic cells and to examinetissues that have high-grade tumors and also tumors located in upper-outer or lower-outer more possibility of metastasis.
Perspectives
this study aimed at comparing the results of H & E and IHC staining’s methods in the detection of lymph nodes micrometastasis. We found that 37.5% of negativelymphnodesinH& Emethodwerepositive inIHC methodandtherewasa significant correlationbetweentumor grade and tumor location with micrometastasis, but no significant correlation with tumor size, patients’ age, and tumor type with lymph node micrometastasis. Therefore, we recommended to detection micrometastasis by IHC method in patients with negative lymph nodes breast carcinoma, who have a higher tumor grade and also tumors located in upper-outer or lower-outer areas of the breast.
mr poorya barand
Read the Original
This page is a summary of: Comparing the Detection of Lymph Nodes Micrometastasis in Breast Cancer by the Hematoxylin and Eosin Staining Method (H & E) and the Immunohistochemical Method (IHC), International Journal of Cancer Management, November 2017, Kowsar Medical Institute,
DOI: 10.5812/ijcm.11743.
You can read the full text:
Resources
Contributors
The following have contributed to this page
