fenugreek and alpha-tocopherol on cadmium induced testicular toxicity

What is it about?

Background: The current study aimed to elucidate the protective role of combined fenugreek and a-tocopherol against cadmium induced histopathological changes in the testes. Materials and methods: Thirty adult male albino rats divided into three equal groups 10 rats each. Group I is the control group. Group II received 5 mg/kg/ day cadmium chloride. Group III received 5 mg/kg/day cadmium chloride and 150 mg/kg/day fenugreek and 100 mg/kg/day of a-tocopherol. The treatment of all groups was done by oral gavage for 60 consecutive days. The testes were removed and subjected to histopathological and ultrastructure study. Results: Rats exposed to cadmium showed severe histopathological changes in the testicular spermatogenic series, many vacuoles and multinucleated giant cells. Treatment with fenugreek and a-tocopherol partially improved the morphological changes, reduced tissue damage and rebuilt of the spermatogonia layer. Conclusions: Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure. (Folia Morphol 2015; 74, 3: 325–334) Key words: cadmium chloride, fenugreek, a-tocopherol, seminiferous epithelium, ultrastructure

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Why is it important?

CONCLUSIONS The results obtained from the current study reveal that fenugreek and a-tocopherol ameliorate histopathological variations of the testicular tissues created by Cd to some extent. These combined substances might be used as a dietary consumption of humans who are exposed to environmental toxins especially Cd.

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