RP-HPLC Forced Degradation Studies of Aztreonam. Pharm Methods, 2018; 9(1): 40-44

What is it about?

Introduction: Aztreonam belongs to the monobactam class of antibiotic used to treat infectious diseases produced by gram-negative bacteria. This work presents the development of LC methods for the estimation of Titled drug in pharmaceutical dosage form and forced degradation studies on four different stress conditions. Degradation studies disclose method abilities on various stress conditions. Forced degradation results can be used for the development of stable dosage form and for the designing of proper storage requirement. The proposed method is accurate, precise, specific and rapid for the estimation of aztreonam injection.

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Why is it important?

Aztreonam is a synthetic monobactam bactericidal antibiotic originally isolated from chromo bacterium violaceum, which is used in the treatment of life threatening infections with susceptible gram-negative aerobic organisms, especially Pseudomonas aeruginosa. Aztreonam acts by inhibiting bacterial cell wall peptidoglycan synthesis. Literature reviews revealed, no stability indicating method of estimation for aztreonam by high performance liquid chromatography has been reported so far except in biological fluids.

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