What is it about?
The aim of this study was to investigate the possible protective effect of Nigella sativa oil (NSO) and compared with the N-acetylcysteine (NAC), an antioxidant which is known to have liver protective effects, against thioacetamide (TAA)-induced liver injury. Accordingly, we aimed to investigate the toxicity of a hepatotoxic agent, thioacetamide, compared the NSO and NAC liver preventive effects in experimental animal model.
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Why is it important?
Our results indicated that NSO improved the liver cell damage caused by TAA, protected against oxidative tissue-damage, contributed to the oxygen radical scavenging activity, increased antioxidant activity and decreased lipid peroxidation. Thus, these results indicate that NSO has protective and antioxidant effects as in the treatment of NAC on the liver injury in rats.
Perspectives
In summary, our data indicated that NSO has protective effects against TAA-induced hepatotoxicity through attenuating lipid peroxidation, improving the antioxidant enzyme status and reducing histopathological damages. Further investigations on the molecular mechanism of effect of the NSO with genetics and immunochemistry studies are required and may have a considerable impact on future clinical treatments of patients with liver injury.
Dr Sedat Bilgiç
Adiyaman Universitesi
Read the Original
This page is a summary of: Protective effect of Nigella sativa oil against thioacetamide-induced liver injury in rats, Medicine Science | International Medical Journal, January 2017, ScopeMed International Medical Journal Management and Indexing System,
DOI: 10.5455/medscience.2016.05.8531.
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