What is it about?
Primary neuroendocrine neoplasm of the breast (PNENB) is a rare subtype of breast cancer, accounting for <1% of all breast tumors [1]. They are subclassified into well-differentiated and poorly differentiated neuroendocrine tumors, as well as invasive breast carcinoma with neuroendocrine features.
Featured Image
Photo by National Cancer Institute on Unsplash
Why is it important?
Well-differentiated tumors show architectural similarity to carcinoids of other sites but lack characteristic neuroendocrine nuclei [2]. A definitive diagnosis relies on histological and immunohistochemical examinations, with neuroendocrine differentiation requiring expression of synaptophysin or chromogranin.
Perspectives
Neuroendocrine tumors of the breast represent a rare and heterogeneous subgroup of breast malignancies. First described in the literature in the 1970s, these tumors share histological and immunohistochemical features with neuroendocrine tumors arising in the gastrointestinal tract and lungs.
Acquire Publications
Read the Original
This page is a summary of: Primary Large Cell Neuroendocrine Carcinoma of the Breast: A Case Report and Literature Review, Journal of Case Reports and Medical History, May 2026, Acquire Publications LLC,
DOI: 10.54289/jcrmh2600109.
You can read the full text:
Contributors
The following have contributed to this page
