What is it about?
Papillary endometrial carcinoma is a rare and aggressive form of uterine cancer, distinct from the more common endometrioid types. It occurs mainly in post-menopausal women, in the absence of hyperestrogenism. Histologically, it is characterized by a complex papillary architecture and marked nuclear atypia.
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Why is it important?
Diagnosis is based on histology and immunohistochemistry, enabling differentiation from serous carcinoma. Treatment is based on a multimodal approach combining surgery, chemotherapy and sometimes radiotherapy. Due to its aggressive nature, the prognosis remains guarded, with a high risk of recurrence and metastasis. Recognition of this entity is helping to optimize management and steer research towards more targeted therapies.
Perspectives
Papillary endometrial carcinoma is a rare and poorly described histological form of endometrial cancer, often confused with serous carcinoma due to their morphological similarity. Although the majority of endometrial cancers are of the low-grade endometrioid type, this papillary variant presents distinct biological and clinical features, associated with more aggressive behavior.
Acquire Publications
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This page is a summary of: Papillary Endometrial Carcinoma: 1 Case Report and Review of the Literature, Journal of Case Reports and Medical History, July 2025, Acquire Publications LLC,
DOI: 10.54289/jcrmh2500138.
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