What is it about?
Pemphigoid of pregnancy (PG) is a rare autoimmune bullous dermatosis, affecting 1 in 20000 to 50000 pregnant women. PG is linked to anti-BP180 autoantibodies whose synthesis follows a breakdown in mother-fetal immunological tolerance.
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Why is it important?
Bullae formation results from a complex mechanism involving TH2 lymphocytes, cytokines and polynuclear cells. PG manifests itself as a pruritic erythematopapular rash of varying extent, progressing to the inconstant but suggestive appearance of vesicles and bullae. The disease progresses to gradual recovery after delivery, sometimes after a post-partum flare-up.
Perspectives
Pemphigoid gestationis is a rare autoimmune bullous dermatosis specific to pregnancy. Its frequency varies from 1/4000 to 1/50,000 pregnancies [1]. The condition is characterized by a pruritic, maculopapular, bullous eruption occurring in the 2nd or 3rd trimester of pregnancy.
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This page is a summary of: Pemphigoide of Pregnancy: Case Report and Review of the Literature, Journal of Case Reports and Medical History, December 2024, Acquire Publications LLC,
DOI: 10.54289/jcrmh2400160.
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