What is it about?
Cancer is essentially a genetic disease, characterized by unclear etiology in many cases, complex pathogenic mechanisms, since in the majority of cancer cases only risk or predisposing factors have been recognized, and unclarified observations concerning organs that are not often affected by malignant tumors such as the small intestine, spleen, heart, and the neurons of the Central Nervous System.
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Why is it important?
A tumor’s appearance and progression presupposes a series of genetic and non-genetic alterations that characterize tumor cells, and are related to self-sufficiency in growth stimuli, insensitivity to anti-growth signals, unlimited replicative potential, angiogenesis promotion, ability to infiltrate surrounding tissues and induce distant metastases, and resistance to apoptosis.
Perspectives
Cell signaling pathways constitute an extremely complex network, that connect and interact with each other, are activated following the effect of various extracellular growth factors such as Vascular Endothelial Growth Factor (VEGF), Platelet-Derived Growth Factor (PDGF), Epidermal Growth Factor (EGF), etc. and intracellular molecules that act as classical oncogenes, such as myc, fos, jun [1,2].
Acquire Publications
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This page is a summary of: The Special Role of JAK/STAT, and Notch Signaling Pathways in Cancer Pathogenesis, Journal of Case Reports and Medical History, October 2023, Acquire Publications LLC,
DOI: 10.54289/jcrmh2300135.
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