What is it about?
PML is a rare opportunistic infection of the central nervous system in the PLHIV Patient. Here, we document a case report where a HIV-positive individual developed Progressive Multifocal Leukoencephalopathy (PML), caused by the reactivation of the John Cunningham virus (JCV) (which leads to the infection of the oligodendrocytes in the brain), Who presented to us with the complaint of the progressive decline in both consciousness and movement.
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Why is it important?
Magnetic resonance imaging (MRI) revealed multiple irregular white-matter lesions in various brain regions which raise the suspicion of PML and the presence of JC viral DNA via the RTPCR in the cerebrospinal fluid (CSF) confirmed the diagnosis of PML.
Perspectives
Progressive Multifocal Leukoencephalopathy (PML) is a rare, severe, and often fatal demyelinating illness of the Central Nervous System (CNS) caused by the JC virus (JCV). The JC virus is a tiny, non-enveloped, double-stranded DNA polyomavirus belonging to the Polyoma viridae family. Its occurrence has notably increased during the AIDS epidemic.
Acquire Publications
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This page is a summary of: Progressive Multifocal Leukoencephalopathy in HIV Patient– A Rare Case Report in India, Journal of Case Reports and Medical History, May 2024, Acquire Publications LLC,
DOI: 10.54289/jcrmh2400130.
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