What is it about?

Inflammatory bowel disease (IBD) is referred to as an inflammatory and ulcerative disease of the small and large intestine and comprises of two different but closely related diseases, Crohn’s disease (CD) and Ulcerative colitis (UC), the conditions that result in chronic inflammation of small and/or large intestine. Pathophysiology of IBD involves oxidative stress, inflammation, and immune responses, while etiology largely encompasses a compound interaction of genetic factors with environmental or microbial factors.

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Why is it important?

The current study focused on the methodology and rationale of exploiting numerous chemical-induced colitis models for assessing the pathogenesis of IBD.

Perspectives

The idea of the review is to discuss different models, which help to generate mechanisms underlying the progression of IBD as well they are helpful to explore and test the potential of treatment drugs that might be useful in treating pathophysiological changes.

JSTR Journal of Science and Technological Researches

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This page is a summary of: Chemical-Induced Animal Models Of Inflammatory Bowel Disease, Journal of Science and Technological Researches, September 2020, Journal of Science and Technological Researches,
DOI: 10.51514/jstr.2.3.2020.1-15.
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