What is it about?
This study presents a comprehensive meta-analysis examining the association between polymorphisms in the TNF-α and IL-10 genes and the risk of systemic lupus erythematosus (SLE). Given the critical roles of TNF-α and IL-10 in regulating inflammation and immune responses, genetic variations in these cytokine genes have been proposed as important contributors to SLE susceptibility.
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Why is it important?
SLE is a complex autoimmune disease with significant clinical variability and a poorly understood etiology, where both genetic and environmental factors contribute to disease development. TNF-α and IL-10 are key cytokines that regulate immune and inflammatory pathways, and polymorphisms in their genes have been widely studied as potential genetic risk factors for SLE. However, previous studies have reported inconsistent and sometimes contradictory results regarding these associations. This meta-analysis is important because it rigorously consolidates existing evidence from diverse populations to provide a clearer, more definitive understanding of the role of TNF-α and IL-10 gene polymorphisms in SLE susceptibility.
Perspectives
The study resolves conflicting evidence on the role of TNF-α and IL-10 gene polymorphisms in SLE susceptibility. It provides a stronger evidence base to guide future research on genetic risk factors in autoimmune diseases. The findings contribute to advancing personalized medicine approaches for SLE diagnosis and risk prediction.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Association of tumor necrosis factor α (rs1800629) and interleukin-10 (rs1800896) gene polymorphisms with systemic lupus erythematosus: a meta-analysis, Reumatologia/Rheumatology, March 2025, Termedia Sp. z.o.o.,
DOI: 10.5114/reum/195431.
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