What is it about?
This article identified 17 genes that can predispose to MODY diabetes as well as their pathogenesis. Fourteen of the genes are well known while 3 are relatively new. These genes are fundamentally embedded in the beta cells, the most common of which are HNF1A, HNF4A, HNF1B, and GCK genes. Mutations in these genes cause β-cell dysfunction, resulting in decreased insulin production and hyperglycemia.
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Why is it important?
As precision medicine is on the horizon, the results of the study will enable medical practitioners to formulate drugs and treatment procedures specific to MODY diabetes, based on the causal gene (s).
Perspectives
The article really broadens my knowledge about subtypes of diabetes, particularly the genetic aspect.
Professor Tajudeen Olanrewaju Yahaya
Federal University Birnin Kebbi
Read the Original
This page is a summary of: Genetics and Pathophysiology of Maturity-onset Diabetes of the Young (MODY): A Review of Current Trends, Oman Medical Journal, May 2020, Oman Medical Journal,
DOI: 10.5001/omj.2020.44.
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