What is it about?
Sickle cell disease (SCD) is a painful, lifelong hemoglobinopathy with substantial morbidities and premature mortality. It is inherited as apoint mutation in the hemoglobin (Hb) beta-globin gene where glu-tamic acid at position 6 is substituted by valine. This mutation provides resistance to malaria, but, in the homozygous form, also SCD is characterized by anemia and painful vaso-occlusive crises (VOCs). The study determined Coagulation profile in addition to Protein S, protein C , fibrinogen level and D dimer in patients with sicke cell disease in study state and during vaso occlusive crisis (VOC)
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Why is it important?
Conclusion: Significant increase in levels of D-dimer during VOC indicating abnormal coagulation and fibrinolysis activation. Reduced levels of natural anticoagulants proteins C and S can be consider as predictive markers indicate hepatic dysfunction in patients with SCD.
Perspectives
The major clinical features of SCD are acute vaso-occlusive manifestations and chronic hemolytic anemia, leading to acute and/or chronic tissue damage and organ dysfunction, so this study provides significant markers for management of the disease
mahmoud abdalla
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This page is a summary of: Comparative study of hypercoagulability change in steady state and during vaso-occlusive crisis among Sudanese patients living with sickle cell disease, African Health Sciences, April 2020, African Journals Online (AJOL),
DOI: 10.4314/ahs.v20i1.45.
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