Cord Blood Hematological Parameters of Fetuses with Thalassemia

What is it about?

Hemoglobinopathies are the most common inherited diseases in humans resulting from impaired globin chain synthesis of hemoglobin. The progression of thalassemia rates is prevented with prenatal screening methods. This study aimed to retrospectively evaluate the hematological parameters of α- and β-thalassemia and normal fetuses aged 17-25 weeks of gestation. Pregnant women who underwent cordocentesis in the second trimester because of the risk of having a baby with thalassemia were included in the study.

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Why is it important?

This study could be a good reference for future studies and prenatal diagnostic applications in emphasizing the importance of changes in the blood parameters of fetuses before molecular genotyping. These hematological data give valuable information to clinicians about the fetus to enlighten families in making appropriate decisions during prenatal diagnosis. The investigated hematological parameters are useful for the differentiation of thalassemias midpregnancy.