What is it about?

We worked on acute acrylamide toxicity and protective effect of L-cysteine. We performed H-E staining, immunohistochemistry (for Bax and PCNA proteins), testosterone measurement, morphometric analysis (seminiferous tubule diameter estimation, multinucleated giant cell counting), body weight, testis weight and testis index calculations.

Featured Image

Why is it important?

Acrylamide is a synthetic chemical and very reactive. It is very widespread. It is used in several industrial sectors, laboratories, etc. Also, acrylamide forms in the foods which are processed at high temperatures (higher than 120 C). So, we indispensably ingest acrylamide by foods in our homes. Here, we sought to reduce/eliminate acrylamide' toxic effect by L-cysteine, an amino acid. In this study, we detected acrylamide to induce multinucleated giant cells in testis in 2 different sites and L-cysteine to protect against this. However, it did not protect against some adverse effects of acrylamide ( testosterone reduction, etc.)

Perspectives

It is very important and very crucial to reduce acrylamide content. Think that even your babies who eat baby biscuits are exposed to acrylamide. As infants and babies have less weight, they are more susceptible to acrylamide toxicity. We should find a way to decrease it or to be protected from it. Here, we tried an amino acid, which is not xenobiotics to body.

Sedat Kacar
Eskisehir Osmangazi Universitesi

Read the Original

This page is a summary of: L-Cysteine Partially Protects Against Acrylamide-Induced Testicular Toxicity, April 2018, Journal of Clinical Research of Pediatric Endocrinology,
DOI: 10.4274/balkanmedj.2017.0830.
You can read the full text:

Read

Contributors

The following have contributed to this page