Predictive biomarker's system of chronicization of inflammation for cancer prevention and treatment

What is it about?

We are witnessing a progressive rise in average age and people with chronic inflammation and degenerative pathologies. Thus, for healthy longevity, it is essential to improve the prevention strategies for these pathologies in both the healthy subjects and those who are already ill and need to undergo clinical treatment. To obtain this it is necessary to overcome the difficulties in the early diagnosis of diseases and effective treatment. Research indicates that it is necessary to identify valid targets and biomarkers to formulate solving strategies. The redox system homeostasis has a primary contribution in the control of inflammation in the healthy state during aging. We have shown, for the first time, that oxidative stress on Trx1/CD30 is a trigger of cancer disease and the selected oxidation and immune products are a valid biomarker’s system in aging and cancer.

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Why is it important?

The selection of prognostic biomarkers for the definition of personalized treatment in aging and CRC onset and/or its progression is not a new topic, but results are still not relevant enough to improve the clinical strategies. Identifying biomarkers able to highlight the risk of developing degenerative processes linked to aging, which could lead to the onset of the disease, is a new challenge.

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