What is it about?
The idea of this study is to mathematically model the relationship between the maternal booking visit lipid profile parameters and the placental indices outcomes. The volume of the placenta which is an indication of the amount of substances it contains including a large amount of trophoblast cells could contribute to the serum lipid transport efficiency. Following the scarcity of literature in relating placental volume to maternal booking lipids, it is tempting to speculate that, the prediction of placental volume by these maternal booking lipids clearly shows foetal dependency on maternal cholesterol supply during first trimester of gestation.
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Photo by João Paulo de Souza Oliveira on Unsplash
Why is it important?
Normal pregnancy is characterized by rising levels of maternal serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) [4]. Physiologically, cholesterol is an essential structural component of the plasma membrane, modulates metabolism, and serves as a precursor of steroid hormones in pregnancy, while the cholesterol is delivered to the materno-foetal transport system via LDL receptors across the placental border to support foetal growth and development through activation and propagation of hedgehog signaling
Perspectives
A significant reduction in surface area, volume, and weight of the placenta results in the slow transfer of essential nutrients to the developing foetus which most often than not leads to stillbirth, a characteristic common in hypertensive pregnant women
Dr. SAMUEL BIMPONG
Kwame Nkrumah University of Science and Technology
Read the Original
This page is a summary of: Relationship between Maternal Booking Visit Lipid Profile and Placental Morphometric Outcome in the Kumasi Metropolis, Ghana, OALib, January 2021, Scientific Research Publishing, Inc,,
DOI: 10.4236/oalib.1107876.
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