Technological Advances in Accelerated Wound Repair and Regeneration Xanya Sofra, Nuris Lampe

What is it about?

We reviewed a number of wound repair, keloid and hypertrophic scar research methods that included lasers, microcurrent and ultra-low energy technologies. Laser research reports short-term improvement in wounds, keloid and hypertrophic scars, but without follow up to control for reoccurrence of keloids or diabetic lesions which generally reoccur following laser treatments. The microcurrent and ultra-low energy studies demonstrate significant healing where age is not a factor with no reoccurrence of diabetic wounds and other skin lesions. Our randomized, double-blind longitudinal research on eight wound repair clinical cases with an age range of 28 - 86, followed for one year, evidenced accelerated healing and no reoccurrence. The number of treatments required for substantial healing depended on the chronicity and severity of the lesion, with chronic severe lesions requiring more treatments, rather than age, a conclusion supported by ultra-low microcurrent research. These results on age-independent wound healing directly contradict a large body of literature postulating that healing is much slower with age due to immune insufficiency, age-accumulated oxidative stress, disrupted cell communications and sustained inflammation.

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Why is it important?

The results of this clinical trial indicated age-independent wound repair in our eight 28 - 86 years old adult subjects of different ethnicities. The number of treatments required for skin repair was related to the chronicity and severity of the lesion, with more chronic severe lesions requiring more treatments irrespective of the subject’s age. Subjects were monitored for at least one year after treatment, confirming the absence of reoccurrence. Our results were consistent with previous research using ultra-low microcurrents demonstrating accelerated wound healing, including diabetic foot lesions, where age was not a factor. Age-independent wound repair seems to defy a number of aging theories postulating inevitable decline and irreversible inflammation. It directly contradicts the concept of “inflammaging” [62], which postulates a slower healing with age due to immune insufficiency, accumulative oxidative stress, increased inflammation and disrupted cell communications predisposing the body with inappropriate levels of growth factors and connexins. We interpreted our results as the outcome of ultra-low energies targeting molecular mechanisms which have the inherent capacity to reverse their paths from injury to self-restoration as seen in the anti-oxidant electron donation that transforms free radicals into stable molecules. The ultra-low energy nanotechnology used is based on the premise that electrons control the gates of potassium, sodium and calcium ion channels at energies below thermal noise, thus allowing the flow of electrons into the system, hindering inflammation by free radicals’ elimination, while possibly, reinstating balance in damaged or over-excited signalling networks. If such electron-driven transformations truly represent a series of molecular time-reversal processes as we hypothesize, it is possible that ultra-low energies may be able to mobilize a number of other inherent time-reversal mechanisms of the body’s cellular machines, repairing the body with the same speed and efficiency at any adult age. The validation of such a hypothesis by future research may have a great impact in several areas of regenerative and possibly preventive medicine. Our sample was small and heterogeneous, including a large variety of skin lesions and aetiologies. Additionally, we did not have a placebo group, and we did not compare the experimental treatment with other methodologies. Our primary goal, however, was to draw attention to the unrealised potential of ultra-low energy technologies in treating dysfunctional tissue, so they can be more widely used and explored by research teams and clinicians treating hard to heal skin lesions.