What is it about?
Women with Polycystic Ovary Syndrome (PCOS) will develop liver involvement proportional with the degree of insulin resistance and consecutively will have greater hyperandrogenaemia. We suggest a potential link between insulin resistance-hyperinsulinism, fatty liver and androgen excess. Insulin resistance will amplify hyperandrogenaemia in PCOS through two mechanisms: 1) IGF-ovary and 2) liver - decrease of cortisol activation from cortisone - increase ACTH - increase of adrenal androgens.
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Why is it important?
Improvement in steatosis treatment could lead to a better outcome of Polycystic Ovary Syndrome.
Perspectives
Our study offered in 2007 an intriguing explanation for high testosterone levels in women with PCOS implying fatty liver. Subsequent more elaborated studies confirmed this hypothesis.
Gheorghe Serpoi
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This page is a summary of: Fatty Liver Amplifies Testosterone Levels in Patients with Polycystic Ovary Syndrome, Acta Endocrinologica (Bucharest), January 2007, ACTA Endocrinologica Foundation,
DOI: 10.4183/aeb.2007.277.
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