An Impact of Biofield Treatment on Spectroscopic Characterization of Pharmaceutical Compounds

What is it about?

The stability of any pharmaceutical compound is most desired quality that determines its shelf life and effectiveness. The stability can be correlated to structural and bonding properties of compound and any variation arise in these properties can be easily determined by spectroscopic analysis. The present study was aimed to evaluate the impact of biofield treatment on these properties of four pharmaceutical compounds such as urea, thiourea, sodium carbonate, and magnesium sulphate, using spectroscopic analysis. Each compound was divided into two groups, referred as control and treatment. The control groups remained as untreated and treatment group of each compound received Mr. Trivedi’s biofield treatment. Control and treated samples of each compound were characterized using Fourier-Transform Infrared (FT-IR) and Ultraviolet-Visible (UV-Vis) spectroscopy. FT-IR spectra of biofield treated urea showed the shifting of C=O stretching peak towards lower frequency (1684→1669 cm-1) and N-H stretching peak towards higher frequency (3428→3435 cm-1) with respect to control. A shift in frequency of C-N-H bending peak was also observed in treated sample as compared to control i.e. (1624→1647 cm-1). FT-IR spectra of thiourea showed upstream shifting of NH2 stretching peak (3363→3387 cm-1) as compared to control, which may be due to decrease in N-H bond length. Also, the change in frequency of N-C-S bending peak (621→660 cm-1) was observed in treated thiourea that could be due to some changes in bond angle after biofield treatment. Similarly, treated sample of sodium carbonate showed decrease in frequency of C-O bending peak (701→690 cm-1) and magnesium sulphate showed increase in frequency of S-O bending peak (621→647 cm-1) as compared to control, which indicated that bond angle might be altered after biofield treatment on respective samples. UV-Vis spectra of biofield treated urea showed shift in lambda max (λmax) towards higher wavelength (201→220 nm) as compared to control sample, whereas other compounds i.e. thiourea, sodium carbonate, and magnesium sulphate showed the similar λmax to their respective control. These findings conclude that biofield treatment has significant impact on spectral properties of tested pharmaceutical compounds which might be due to some changes happening at atomic level of compounds, and leading to affect the bonding and structural properties of compounds.

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Why is it important?

Pharmaceutical industries are an important component of health care systems which are largely driven by scientific discovery and development of various chemical and biological agents for human and animal health. The pharmaceutical industry is based primarily upon many organic and inorganic chemicals, which are used as raw materials, serve as reactants, reagents, catalysts, counter ions and solvents. However these chemicals exhibit a wide range of pharmacological activity and toxicological properties [1]. Although the pharma industries are dominated by organic compounds and drugs, the inorganic compounds also focus their attention due to their therapeutic potential such as neurological, anticancer, antimicrobial, antiulcer, antiviral, anti-inflammatory, cardio vascular and insulin-mimetic agents. Moreover, inorganic compounds also play an important role as counter ions in drugs, which influence the solubility, stability, and hygroscopicity of active pharmaceutical ingredients [2]. The compounds selected in this study for biofield treatment are urea, thiourea, sodium carbonate and magnesium sulphate, which have wide applications in pharmaceutical industry. Urea, a white crystalline powder is commonly used in denaturing and solubilising proteins in the biopharmaceutical industry. It serves an important role in the metabolism of nitrogen-containing compounds by animals and is the main nitrogen-containing substance in the urine of mammals. It is small hydrophilic molecule, present in all taxa, and widely used as protein denaturant in in vitro unfolding/refolding experiments [3]. It is also used clinically as emollient and keratolytic agent in treatment of skin related diseases [4]. Thiourea is an organosulfur compound which is utilized in organic synthesis of various compounds and pharmaceuticals like sulfathiazoles, thiouracils, tetramizole and cephalosporins. Moreover, it was also used as thyroid depressant during 1940s [5,6]. Sodium carbonate, commonly known as washing soda, is sodium salt of carbonic acid. Naturally it exists in the form of crystalline heptahydrate; however it readily effloresces to form a white powder which is monohydrate [7]. Sodium carbonate (Na2CO3) is a food additive and used as carbonating agent, anti-caking agent, raising agent, and stabilizer. Its activities are also reported as an alkalizing agent, used in lotion or bath in the treatment of scaly skin in pharmaceuticals [8]. Magnesium sulphate is commonly known as Epsom salt, and used both externally and internally in pharmaceutical preparation. In addition, Epsom salt is also used as bath salts and for isolation tanks. Oral magnesium sulphate is commonly used as a saline laxative or osmotic purgative. Magnesium sulphate is the main compound for preparation of intravenous magnesium [9,10]. In all these four compounds, stability plays a crucial role in pharmaceutical preparations, which is directly related to its structural and atomic bonding properties. Currently, in pharmaceutical industries stability of these compounds is modulating through altering temperature and pH conditions [11]. Thus, it is important to evaluate an alternate strategy, which could alter the structural and bonding properties and that can affect the stability in these compounds. Biofield is the scientific term for the biologically produced ultra-fine electromagnetic energy field that can function for regulation and communication within the organism [12]. It is already demonstrated that electrical current exists inside the human body in the form of vibratory energy particles like ions, protons, and electrons and they generate magnetic field in the human body [13,14]. This electromagnetic field of the human body is known as biofield and energy associated with this field is known as biofield energy [15,16]. Thus, a human has the ability to harness the energy from environment or universe and can transmit the energy into any living or non-living object around this Globe. The object(s) always receive the energy and respond into useful way via biofield energy. This process is termed as biofield treatment. Mr Trivedi’s biofield treatment (The Trivedi Effect®) is recognized as an alternate approach to alter the several physical and structural properties of metal powder at atomic level [17-21]. The biofield treatment has also transformed the characteristics in several other fields like biotechnology [22,23], microbiology [24,25], and in agricultural science [26,27]. IR spectroscopy which deals with the infrared region and UV-Vis spectroscopy which deals with ultraviolet-visible spectral region of the electromagnetic spectrum are used in analytical chemistry for the quantitative determination of different analytes, such as transition metal ions, highly conjugated organic compounds, and biological macromolecules [28]. They can provide analytically useful information on a large variety of compounds, ranging from small inorganic ions to large organic molecules [29]. Recently, effect of biofield treatment on ceramic oxide nano powders was studied using infrared spectroscopy, which reported that structural and bond properties were altered after treatment [30-33]. Hence based on the outstanding results achieved on different materials and considering the pharmaceutical applications of these four compounds, the present study was undertaken to evaluate the impact of biofield treatment on the spectroscopic characteristics of urea, thiourea, sodium carbonate, and magnesium sulphate.

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