Iatrogenic depression with anti-epileptic drugs"commnetary"

What is it about?

e main issue in treatment of partial seizures with depressed mood is to provide physician and patient counselling about this co-morbid diseases and the precautions in administration of the recommended anti-epileptic drugs regarding: proper diagnosis- therapeutic drug monitoring- preferable monotherapy of partial seizures using the appropriate drug to the clinical condition of the depressed patient- Small dose of co-administered SSRIs and long duration of administration together with the selected antiepileptic drugs-Gradual withdrawal and take care of special population esp. pregnant females.

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Why is it important?

The dose adjustment and the frequent therapeutic drug monitoring of any selected anti-epileptic drug in partial seizure with depressed mood are mandatory to achieve both the efficacy and safety of these anti-epileptic drugs and to reduce the incidence of depression or the augmentation of the clinical severity of depression.