Increasing the Degrees of Freedom for Treating Painful Diabetic Neuropathy

Jan M. Keppel Hesselink
  • Journal of Pain & Relief, January 2015, OMICS Publishing Group
  • DOI: 10.4172/2167-0846.1000e119

What is it about?

Palmitoylethanolamide is available without prescription and as there are no interactions to be expected, it should be more often considered as a co-analgesic in diabetic pain. PeaPure (capsules 400 mg) and Normast (tablets 600 mg) are so far the only PEA formulations which have been evaluated for safety and efficacy by physicians. Both formulations induce a clear increase in plasma levels of PEA.

Why is it important?

Because patients with diabetic neuropathic pain often cannot tolerate classical analgesics. PEA has a very good tolerability profile and should be used more often. Dose recommendation is 2-3 times a day 400-800 mg capsules.


jan keppel hesselink
Institute Neuropathic Pain

I treat patients suffering from diabetic neuropathy often with PEA and topical analgesic creams (amitriptyline, ketamine, baclofen). Many patients report improvements without side effects.

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