Primumnon Nocere: Supplements As Analgesics, A Neglected Area

Jan M. Keppel Hesselink
  • Journal of Pain & Relief, January 2013, OMICS Publishing Group
  • DOI: 10.4172/2167-0846.1000e116

Analgesics without side-effects and how to use palmitoylethanolamide and alpha-lipoic acid!

What is it about?

No to do harm is an important guide for MDs in treating pain patients. Not to do harm is possible with analgeiscs like the body-own molecule palmitoylethanolamide. Since 2015 we know its NNT in neuropathic pain: 1.5. Thus each pain specialist should start treatment of pain with palmitoylethanolamide (3 times 400 mg/day).

Why is it important?

This is important while there ar too many patients with low analgesics compliance. PEA can changes this.


jan keppel hesselink
Institute Neuropathic Pain

I think MDs should start triggering body-own mechanisms to counteract pain, such as with palmitoylethanooamide. Its proven efficacy (NNT 1.5) and absence of troublesome side effects nearly dictates to give this compound a central place in analgesia.

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