What is it about?

In human metabolic diseases, the beneficial effects of estradiol administration justify that estrogen receptors (ERs) confer advantageous intracellular signals if estrogen supply is sufficient. In estrogen deficient states or in case of defective ER signaling an increased prevalence of type 2 diabetes and its comorbidities may be characteristic.

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Why is it important?

Hyperestrogenism is not a causal factor of human diseases, rather a defensive counteraction, which aims to breakthrough the resistance of ERs. Failure of this defensive estrogen overproduction leads to the development of diseases, while the patient exhibits misleading clinical signs of estrogen deficiency.


All players of cellular glucose uptake, from insulin secretion to the expression of intracellular glucose transporters are dependent on the appropriate estrogen signaling. Defective transcriptional activity of estrogen receptors leads to metabolic syndrome and type 2 diabetes. We are on the way to regard estrogens as antidiabetic agents.

professor Zsuzsanna Suba
National Institute of Oncology Budapest

Read the Original

This page is a summary of: Low Estrogen Exposure and/or Defective Estrogen Signaling Induces Disturbances in Glucose Uptake and Energy Expenditure, Journal of Diabetes & Metabolism, January 2013, OMICS Publishing Group,
DOI: 10.4172/2155-6156.1000272.
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