Estrogen signaling provides the surveillance of cellular health and increases insulin sensitivity
What is it about?
In human metabolic diseases, the beneficial effects of estradiol administration justify that estrogen receptors (ERs) confer advantageous intracellular signals if estrogen supply is sufficient. In estrogen deficient states or in case of defective ER signaling an increased prevalence of type 2 diabetes and its comorbidities may be characteristic.
Why is it important?
Hyperestrogenism is not a causal factor of human diseases, rather a defensive counteraction, which aims to breakthrough the resistance of ERs. Failure of this defensive estrogen overproduction leads to the development of diseases, while the patient exhibits misleading clinical signs of estrogen deficiency.
The following have contributed to this page: professor Zsuzsanna Suba