Editorial piece discussing the issues around disulfide conjugation strategies.

What is it about?

Therapeutics against cancer and viral infections commonly suffer from several drawbacks including non-selective cytotoxicity, high immunogenicity and low circulation half-lives. The last decade has shown that these therapeutics have embraced conjugation of synthetic polymers and antibodies to therapeutic and cytotoxic payloads. Thiol-thiol coupling (disulfide conjugation) has been a tremendously popular conjugation strategy, in part due to its orthogonality, is amenable to biological and non-biological therapeutics and allows for modulating the strength of the conjugation through groups adjacent to the disulfide.

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Why is it important?

The ease of disulphide-conjugation have been overshadowed by mixed results obtained from in vitro and in vivo experiments. This piece highlights the failures and successes of disulfide chemistry in light of these mixed results.

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