Voltammetric analysis of dantrolene and its active metabolite with indomethacin in rat plasma

What is it about?

In many cases of back pain, non-steroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants medications are prescribed, usually as combined therapy. When the muscle relaxants are concurrently prescribed with NSAIDS, their effect is reported to be additive and greater pain relief is achieved. The work presents validated electrochemical method for the analysis of common widely co-administered drugs, dantrolene (DAN) as muscle relaxant and indomethacin (IND) as NSAID, in plasma. The work can be utilized in future for further pharmacokinetics and clinical investigations which deal with drug-drug interaction and dose adjustment. No reported technique (chromatography or any other technique) was found in literature investigating DAN/IND simultaneous analysis in plasma. The common methods used in bioanalytical field incorporate sophisticated techniques. However, in the present study, we offer sensitive, simple technique with low organic solvents consumption and low waste production. The proposed work is directed towards quantification of analytes in animal biological samples (rat plasma). The work analyzes IND and DAN with DAN active metabolite in plasma using a voltammetric method with levels that could be applied to human plasma.

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