What is it about?
Drug metabolite which exposes human more than 10% of total drug-related exposure is considered important. Analysis of metabolite is sometimes imprecise relative to parent drug. Thus, confidence interval calculated from accuracy / precision of the analytical method can be useful in determining the importance of the metabolite.
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Why is it important?
By using this approach, we do not have to stick to pre-defined accuracy / precision criteria of the analytical methods. This allows flexible research activity in studying drug metabolites.
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This page is a summary of: Evaluating exposure using confidence intervals: implication in tiered quantitation of metabolites for safety risks, Bioanalysis, October 2018, Future Science, DOI: 10.4155/bio-2018-0217.
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