Absence of BRAF mutation in rare neuroendocrine tumours

What is it about?

This study investigates the occurrence of the BRAF V600E mutation in pheochromocytomas (PHEOs) and paragangliomas (PARAs)

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Why is it important?

A cohort of 64 PHEO/PARA were screened for the BRAF V600E mutation using direct Sanger sequencing and QRT-PCR.Taken together with all previously screened tumors up to date, only 1 V600E BRAF mutation has been found among 427 PCCs. The findings imply that the V600E BRAF mutation is a rare event in PHEO/PARA.