An Interpretation of the Ancestral Codon from Miller's Amino Acids and Nucleotide Correlations in Modern Coding Sequences

Nicolas Carels, Miguel Ponce de Leon
  • Bioinformatics and Biology Insights, January 2015, SAGE Publishing
  • DOI: 10.4137/bbi.s24021

Interpreting the ancestral codon from Miller’s amino acids and nucleotide correlations in modern CDS

What is it about?

Purine bias, which is usually referred to as an “ancestral codon”, is known to result in short-range correlations between nucleotides in coding sequences, and it is common in all species. We demonstrate that RWY is a more appropriate pattern than the classical RNY, and purine bias (Rrr) is the product of a network of nucleotide compensations induced by functional constraints on the physicochemical properties of proteins. Through deductions from universal correlation properties, we also demonstrate that amino acids from Miller’s spark discharge experiment are compatible with functional primeval proteins at the dawn of living cell radiation on earth. These amino acids match the hydropathy and secondary structures of modern proteins.

Why is it important?

This report establish a link between modern proteins and primeval genetic code, which has its importance concerning the evolution of the genetic code. This issue is hot since it concerns a chapter of the origin of life at the moment where astronomers search for earth like exoplanets in the universe.


Nicolas Carels (Author)
Oswaldo Cruz Foundation

The functionalities and evolution of primeval proteins and enzymes could be checked in test tube in the context of RNA-first or protein-first, which is a subject still intensely debated in search of the path that evolution took at the beginning of life origin.

The following have contributed to this page: Nicolas Carels

In partnership with: