What is it about?
The survival of oral squamous‑cell carcinoma (OSCC) patients remains poor despite recent treatment advances. A sensitive and specific biomarker is important in screening high‑risk patients salivary TNF‑α can be used as a marker for predicting leukoplakia and oral cancer. The study also showed a significant correlation between clinical staging and histopathological grading of OSCC and TNF‑α level.
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Why is it important?
Over the years, numerous biomarkers for OSCC have been suggested to foresee the prognosis of OSCC patients,[20] but there is still an ongoing debate regarding their clinical implementation.[21] Clinical trials could be obtained to prove clinical importance of TNF‑α for survival rate, tumor recurrence, nodal metastasis, and resistance of therapy. Further clinical investigations are, therefore, required.
Perspectives
future studies, including these potential markers as a panel of biomarkers to aid in the early diagnosisof OSCC can be carried out.
Dr rathy ravindran
azeezia college of dental science and research
Read the Original
This page is a summary of: Evaluation of tumor necrosis factor: Alpha in the saliva of oral cancer, leukoplakia, and healthy controls – A comparative study, Journal of International Oral Health, January 2019, Medknow,
DOI: 10.4103/jioh.jioh_202_18.
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