Influence of Interleukin Polymorphisms on the Risk of Recurrent Pregnancy Loss

What is it about?

This comprehensive meta-analysis examines the relationship between polymorphisms in key interleukin genes specifically IL‑1β (-511 T > C), IL‑6 (-174 G > C), and IL‑10 (-1082 A > G and -592 C > A)and the risk of recurrent pregnancy loss (RPL) across diverse populations. By reviewing 58 case-control studies encompassing a total of 13,696 participants and applying rigorous inclusion criteria, the authors calculated pooled odds ratios and confidence intervals using fixed- or random-effects models depending on heterogeneity. Their findings demonstrate significant associations: IL‑1β (-511 T > C), IL‑6 (-174 G > C), and both IL‑10 variants are linked to increased RPL risk, particularly in Asian populations. The study also assessed study quality using the Cochrane RoB Tool and evaluated publication bias and statistical power. By consolidating evidence across many studies, this work clarifies genetic contributions to RPL and lays the groundwork for future research into immune-mediated mechanisms and personalized reproductive care tailored to genetic risk profiles.

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Photo by Filipp Romanovski on Unsplash

Photo by Filipp Romanovski on Unsplash

Why is it important?

This paper is important because it systematically consolidates and clarifies the role of interleukin gene polymorphisms in the risk of recurrent pregnancy loss (RPL), a distressing and poorly understood reproductive condition. By identifying significant associations between specific IL-1β, IL-6, and IL-10 variants and RPL—particularly in certain ethnic populations—it enhances our understanding of the immune and inflammatory pathways involved in pregnancy maintenance. The findings not only improve insight into the genetic basis of RPL but also support the development of predictive biomarkers and personalized therapeutic approaches, contributing to better diagnosis, prevention, and management of RPL in clinical settings.

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