What is it about?
Resveratrol (RSV) is a biomolecule that has been demonstrated in numerous studies to possess therapeutic potentials with multiple targets. Despite the reported low bioavailability, it could exhibit novel role in clinical pain management. The systemic analgesic and anti‑inflammatory effects of RSV in comparison to diclofenac and etoricoxib was investigated.
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Why is it important?
RSV may be useful in the management of acute and chronic pain with significant inflammatory components
Perspectives
RSV may elicit its analgesic actions by inhibiting the direct activation of nociceptors. It may be suggested that systemic RSV at a dose of 50 mg/kg in Wistar rats significantly reduces inflammation comparable to etoricoxib, but possibly less potent than diclofenac.
Emeka John Dingwoke
Ahmadu Bello University
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This page is a summary of: Analgesic and anti-inflammatory effects of resveratrol in rat models of pain: Any role in clinical pain management?, Archives of Medicine and Surgery, January 2018, Medknow,
DOI: 10.4103/archms.archms_54_17.
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