What is it about?
Angiogenesis is the formation of new blood vessels from the endothelium of existing blood vessels. Angiogenesis is a fundamental process that is responsible for tumour growth, progression and metastasis. Tumors cannot grow beyond 1-2 mm in size unless they are adequately vascularised. This is because of the fact that, cancer cells also require delivery of oxygen, nutrients and removal of waste products for their survival and growth
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Why is it important?
The conventional approach to the treatment of cancerous growth consists of surgery, chemotherapy and radiotherapy. Basically they all target removal or destruction of a cancerous mass. A tumour depends on angiogenesis for its growth and dissemination, so blocking this process reduces tumour growth and dissemination
Perspectives
1. The long-term survival and overall benefit of advanced disease are limited and same may acquire resistance and become refractory to anti-VEGF therapy. The mechanism of developing resistance is yet to be evaluated
Sujan Narayan Agrawal
Read the Original
This page is a summary of: The basic molecular biology of angiogenesis and its implication in anticancer therapeutics, Archives of International Surgery, January 2015, Medknow,
DOI: 10.4103/2278-9596.167472.
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