What is it about?

Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal cord.

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Why is it important?

VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18.


Using VX-765 may be a potential strategy for treating spinal cord injury.

He-Zuo Lü
Bengbu Medical College

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This page is a summary of: VX-765 reduces neuroinflammation after spinal cord injury in mice, Neural Regeneration Research, January 2021, Medknow, DOI: 10.4103/1673-5374.306096.
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