Immunohistochemical study of polycystin-1 in dentigerous cysts

Thavarajah Rooban; Elizabeth Joshua; UmadeviModuali Rao; Kannan Ranganathan; JaishlalMariachelliah Nadar Singarayan

doi:10.4103/0970-9290.152198

What is it about?

Proposes a new hypothesis with proof of concept for the role of polycystin - a protein known to cause cysts in kidney, ovaries, liver, pancreas etc. to be involved in dilated dental follicles and dentigerous cysts and not in normal follicles

Why is it important?

Newer dimension and understanding of cystogenesis is proposed. Preventive extraction of impacted teeth has been a issue of contention. Hopefully this mechanism would help to unravel the exact mechanism of dentigerous cyst transformation

This page is a summary of: Immunohistochemical study of polycystin-1 in dentigerous cysts, Indian Journal of Dental Research, January 2014, Medknow,
DOI: 10.4103/0970-9290.152198.
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Immunohistochemical study of polycystin-1 in dentigerous cysts
Background: The alterations involved in step-wise transformation of a dental follicle to dentigerous cyst (DC) is not clearly known. Primary cilium and its protein have been hypothesized to be associated with DC. Mutation of a ciliary protein, polycystin-1 (PC1) is associated with autosomal dominant polycystic kidney disease. This study was performed to assess the immunohistochemical expression of PC1 between DC and postfunctional follicular tissue (PFFT).

Contributors

The following have contributed to this page

Professor Rooban Thavarajah
Ragas Dental College and Hospital

Dentigerous cyst - newer dimension and hypothesis proposed - New molecule - Polycystin - a protein

What is it about?

Why is it important?

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