What is it about?
Accumulation of oral cancer incidence among non-smoker, non-drinker elderly female patients is conspicuous. Structures of upper aerodigestive tract are moderately estrogen dependent; they are endangered by cancer development only in case of deep estrogen deficiency. By contrast, female reproductive organs have high estrogen demand and even a mild defect of estrogen surveillance may be cancer risk factor for them.
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Why is it important?
Controversial results on the carcinogenic capacity of estrogen derive from the misinterpretation of the importance of estrogen signaling in cancer prevention.
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This page is a summary of: Common soil of smoking-associated and hormone-related cancers: estrogen deficiency, Oncology Reviews, December 2011, PAGEPress Publications,
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