Propofol-based sedation does not increase rate of perforation during colonoscopic procedur

Somchai Amornyotin, Ungkab Prakanrattana, Udom Kachintorn, Wiyada Chalayonnavin, Siriporn Kongphlay
  • Gastroenterology Insights, February 2010, PAGEPress Publications
  • DOI: 10.4081/gi.2010.e4

Propofol-based sedation does not increase rate of perforation during colonoscopy

What is it about?

Sedation-related colonoscopic perforation (CP) has been under much debate. Our aim was to assess and compare the CP rate during colonoscopy by using sedation with or without propofol adjuvant. All patients who underwent colonoscopic procedure at the WGO Endoscopy Training Center, Siriraj Hospital, Thailand from March 2005 to October 2007 by using the intravenous sedation (IVS) technique were analyzed.

Why is it important?

After matching the indications of procedure, there were 2022 colonoscopies in group A and 512 colonoscopies in group B. Colonoscopic procedures were performed by staff endoscopists (10.8%) or residents and fellows (89.2%). The characteristics of patients and sedative agents used in perforated patients in both groups were not significantly different. In group A, five patients (0.25%) suffered from perforation and two of them died. In group B, one patient (0.20%) had CP; the difference was not significant (P=0.829).


Somchai Amornyotin
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Our data showed that colonoscopy under propofol-based sedation did not increase the perforation rate. Serious complications are uncommon.

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The following have contributed to this page: Somchai Amornyotin