What is it about?
Key findings include: Eosinophilic Infiltration: DQ6/CD4 null mice showed significant eosinophilic infiltration in the bronchoalveolar lavage and lung tissue, unlike DQ8/CD4 null mice1. Airway Reactivity: DQ6/CD4 null mice had moderately elevated airway reactivity to methacholine compared to their CD4+ counterparts. Cytokine Production: The immune response in DQ6/CD4 null mice involved Th1/Th2-type cytokines and SRW-specific antibodies, contrasting with a direct Th2 response in DQ6/CD4+ mice. Double-Negative T Cells: The study identified an expansion of double-negative (CD4− CD8−) T cells in SRW-treated DQ6/CD4 null mice, which produced IL-4, IL-5, IL-13, and IFN-γ.
Featured Image
Why is it important?
This research highlights the complex role of HLA-DQ-restricted CD4+ and double-negative T cells in allergic responses
Perspectives
The study highlights the complex interplay between HLA-DQ molecules, CD4+ T cells, and double-negative T cells in allergic responses. It underscores the importance of CD4+ T cells in regulating the immune response and suggests that in their absence, alternative immune pathways can lead to significant allergic inflammation.
Svetlana Chapoval
University of Maryland School of Medicine
Read the Original
This page is a summary of: Allergic Inflammatory Response to Short Ragweed Allergenic Extract in HLA-DQ Transgenic Mice LackingCD4Gene, The Journal of Immunology, January 2002, The American Association of Immunologists,
DOI: 10.4049/jimmunol.168.2.890.
You can read the full text:
Contributors
The following have contributed to this page
