What is it about?
Large bone defects in the head and face region are clinically challanging to treat. With certain size (critical size) bone defects will not heal spontaneously and defects will remain unrepaired. Our research was done in dogs to investigate if bone critical-size defects in the head region would repair with the use of silica calcium phosphate nano composite (SCPC) scaffolds (previously shown good in bone regeneration) when used alone or in combination with stem cells that were isolated from adipose tissue and directed to be osteoblasts in comparison to empty defects.
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Why is it important?
Critical-size defects treated with grafts (either SCPC alone or SCPC with stem cells ) were repired after 3 months while ungrafted defects were still open and unrepaired. Our research showed that defects grafted by SCPC with stem cells were better in terms of percentage of bone formation and SCPC scaffold material remnant resorption than grafts treated with SCPC alone. Our research gives a hope for treatment of large bone defects in maxillo facial area with bone engineering stratigies in the near future without harvesting a lot of bone from other areas in the body (autogenous grafts).
Perspectives
This research was acccomplished by great collaboration between scientists from different fields e.g physics , cell culture and dental surgeons. Whole group worked really hard with great enthuthiasim for more than 4 years and finally we hope it would help patients in the near future and pave the way for other researchers.
Mervat El-Deftar
Pathology Department, National Cancer Institute, Cairo University
Read the Original
This page is a summary of: Regeneration of Critical-Size Canine Calvarial Defect by Silica-Calcium Phosphate-Composite (SCPC) and Human Adipose Derived Stem Cells, Key Engineering Materials, November 2017, Trans Tech Publications,
DOI: 10.4028/www.scientific.net/kem.758.264.
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