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Why is it important?
This work is timely as the prevalence of vitamin B-6 insufficiency (marginal status) is as high as 30% in the North American population. Furthermore, the ingestion of whole flaxseed is increasing as consumers seek out products with this ingredient due to its content of omega-3 fatty acids and bioactive lignans. As such, this work positions a plausible scenario regarding the exposure to nutritional co-insults.
Perspectives
The concept of nutritional co-insults intrigues me as pre-clinical/animal-derived knowledge regarding tolerances to toxicants/drugs is generally derived from models that are well nourished. The current work highlights one example where dietary exposure to an an anti-nutritive factor yielded evidence of no adverse effects in a rodent model receiving adequate (or excessive) micronutrients. However, by limiting the status of a key nutrient, a different conclusion can be drawn. This begs the question as to the translational potential of animal-derived toxicity data that does not consider the status of key nutrients in the target population of interest.
Dr James D. House
University of Manitoba
Read the Original
This page is a summary of: A Vitamin B-6 Antagonist from Flaxseed Perturbs Amino Acid Metabolism in Moderately Vitamin B-6–Deficient Male Rats1–3, Journal of Nutrition, November 2015, Oxford University Press (OUP),
DOI: 10.3945/jn.115.219378.
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