What is it about?
Specific plant derived micronutrients, including carotenoids [alpha-carotene, beta-carotene (cis+trans), beta-cryptoxanthin, lutein+zeaxanthin, and total lycopene], vitamin A (retinol), retinyl esters , vitamin C, and vitamin E have antiinflammatory and antioxidant effects, properties shown to reduce oxidative stress, a process that accompanies the pathogenesis of many chronic diseases such as the metabolic syndrome (MetS) . We investigated the associations between these levels and features of MetS in over 4000 adolescents aged 12-19 y using cross-sectional data from NHANES 2001-2006 (n = 782-4285). cross-sectional data from NHANES 2001-2006 (n = 782-4285)adolescents representative of the US population.
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Why is it important?
MetS prevalence was estimated at 7% among boys and 3% among girls. In adjusted models, adolescents with MetS had consistently lower carotenoid concentrations compared with their counterparts without MetS. Total carotenoids were also inversely related to HOMA-IR and CRP. Vitamin C was inversely related to uric acid level and MetS binary outcome. Vitamin E had no association with MetS, particularly after controlling for serum cholesterol and triglycerides. Retinol+retinyl esters exhibited an inverse relationship with CRP and a positive relationship with uric acid and HOMA-IR as well as MetS binary outcome.
Perspectives
In U.S. adolescents, serum carotenoid concentrations are inversely associated with MetS status, HOMA-IR, and CRP, whereas serum vitamin C was inversely related to MetS status and serum uric acid. Vitamin E had no consistent association with MetS, whereas vitamin A (retinol)+retinyl esters had a positive relationship with HOMA-IR, uric acid, and MetS, while being inversely related to CRP. Carotenoids are robust markers of fruit and vegetable intake and may implicate low intake or absorption of these nutrients.in children at risk for MetS. These associations have significant public health implications and call for further studies to determine the appropriate concentrations needed to promote a healthy metabolic state in children and adults. .
J. Atilio Canas
Nemours Health System
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This page is a summary of: Serum Antioxidant Concentrations and Metabolic Syndrome Are Associated among U.S. Adolescents in Recent National Surveys, Journal of Nutrition, July 2012, American Society for Nutrition,
DOI: 10.3945/jn.112.160416.
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