What is it about?
This review investigates how genetic susceptibility influences an individual's health when exposed to air pollution. We analyzed 16 studies to examine how gene-environment interactions affect disease. We highlight the genes involved in regulating oxidative stress, inflammation, and DNA repair, which are thought to influence individual variations in response to air pollutants like PM2.5, PM10, and nitrogen oxides.
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Why is it important?
This study is important because it provides new insights into why some people are more vulnerable to the harmful effects of air pollution than others. By identifying the genes involved, we can pave the way for a 'precision health' approach tailored to individual genetic profiles, allowing for more effective diagnosis and prevention of pollution-related diseases.
Perspectives
As researchers, we acknowledge that studies on gene-environment interactions still have limitations, particularly the lack of longitudinal studies and population diversity. We hope this review can serve as a foundation for future studies that will address these limitations and further investigate how genes and the environment work together to influence health.
Hari Krismanuel
Universitas Trisakti
Read the Original
This page is a summary of: Exploring genetic susceptibility to air pollution and its implications for disease risk and precision health: A scoping review, AIMS Public Health, January 2025, American Institute of Mathematical Sciences (AIMS),
DOI: 10.3934/publichealth.2025046.
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