Tracheal Responsiveness to Histamine and Histamine (H1) Receptor Blockade by Chlorpheniramine in an Animal Model of COPD

What is it about?

Airway hyperresponsiveness (AHR) is the main feature of asthma which also excite in chronic obstructive pulmonary diseases (COPD). However, the mechanism of AHR is uncertain due to the complexity stimuli action used for measuring AHR. The mechanism of competitive antagonism blockade, which is measured as concentration ratio-1 (CR-1) is far simpler than that of agonist and depends only on drug delivery to the receptor sites and receptor affinity. Therefore, in this study, we have examined the histamine receptor blockaded by chlorpheniramine on isolated tracheal chains of a model of COPD compared to control guinea pigs.

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Why is it important?

The enhanced histamine receptor blockade increased tracheal response to histamine in tracheal chains of COPD animals and significant correlation between these two phenomena may indicate that increased drug delivery to the receptors could be a determinant factor for bronchial responsiveness to stimuli in COPD.