Cyclopiazonic acid: 50 years of research
What is it about?
Mycotoxin cyclopiazonic acid (CPA) an indole tetramic and a lipophilic monobasic acid was first discovered and characterized in year 1968. CPA is produced by several Penicillium species (P. griseofulvum, P. camemberti, P. commune, P. dipodomyicola) and Aspergillus species (A. flavus, A. oryzae, and A. tamarii). CPA has been reported to occur in food commodities (e.g. oilseeds, nuts, cereals, dried figs, milk, cheese and meat products). CPA is frequently detected in e.g. peanuts and maize. After ingesting CPA-contaminated feeds, test animals display severe gastrointestinal upsets and neurological disorders. CPA is toxic to several animal species, such as rats, pigs, guinea pigs, poultry and dogs.
Why is it important?
Consequently, CPA did not attract the attention of the scientific community. Scientific interest in CPA increased in 1977. It was demonstrated that Aspergillus flavus could produce CPA in food and feed.
The following have contributed to this page: Vladimir Ostry