Cyclopiazonic acid: 50th anniversary of its discovery

V. Ostry, J. Toman, Y. Grosse, F. Malir
  • World Mycotoxin Journal, February 2018, Wageningen Academic Publishers
  • DOI: 10.3920/wmj2017.2243

Cyclopiazonic acid: 50 years of research

What is it about?

Mycotoxin cyclopiazonic acid (CPA) an indole tetramic and a lipophilic monobasic acid was first discovered and characterized in year 1968. CPA is produced by several Penicillium species (P. griseofulvum, P. camemberti, P. commune, P. dipodomyicola) and Aspergillus species (A. flavus, A. oryzae, and A. tamarii). CPA has been reported to occur in food commodities (e.g. oilseeds, nuts, cereals, dried figs, milk, cheese and meat products). CPA is frequently detected in e.g. peanuts and maize. After ingesting CPA-contaminated feeds, test animals display severe gastrointestinal upsets and neurological disorders. CPA is toxic to several animal species, such as rats, pigs, guinea pigs, poultry and dogs.

Why is it important?

Consequently, CPA did not attract the attention of the scientific community. Scientific interest in CPA increased in 1977. It was demonstrated that Aspergillus flavus could produce CPA in food and feed.


Vladimir Ostry
National Institute of Public Health in Prague

Selected recent research topics such as a research on the diversity and genetic variability of CPA production in Aspergillus flavus and on the problem of biocontrol strategy for use of the non-aflatoxigenic strains of A. flavus and CPA as a pathogenicity factor for A. flavus were researched.

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The following have contributed to this page: Vladimir Ostry