unraveling Alzheimer's Disease

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AD is the most common neurodegenerative disease and is widely recognized as a global challenge for society and health‑care providers. EOAD is inherited via an autosomal dominant pattern and predominantly governed by three rare mutation genes as follows: APP, PSEN1, and PSEN2, through a common mechanism of altered Aβ production. In addition, APOE has been recognized as a major genetic risk factor for LOAD. Furthermore, various genes have been implicated in LOAD; these genes primarily mediate the Aβ level, while certain genes are implicated in the metabolic pathway and neuroinflammation. Further studies are required to unravel the complete picture of genetics behind this devastating disease and to provide insight into novel therapeutic targe

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