What is it about?
Colon Cancer Associated Transcript 1 (CCAT1), a lncRNA located in chromosome 8q24, close to the c-Myc gene, has been reported to be overexpressed in many human cancers. The study analyzed the expression of CCAT1, c-Myc and the miRNAs miR155-5p, let7b-5p, miR490-3p and miR218-5p sponged by CCAT1 in oral tissue samples by qRT-PCR.
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Why is it important?
CCAT1 overexpression significantly downregulated miR155-5p and let7b-5p and oral cancer cases expressing a high level of CCAT1 presented poor therapeutic outcome. A high level of c-Myc expression was observed in all CCAT1 overexpressing cases.
Perspectives
Functioning as ceRNA, CCAT1 has been reported to downregulate miR155-5p, let7b-5p and miR490-3p through sequestration and miR218-5p by epigenetic regulation in many cancers. miR155‑5p and let7b‑5p were significantly downregulated in oral cancer. c-Myc and CCAT1 are concomitantly overexpressed in oral squamous cell carcinomas and are associated with clinical outcome. CCAT1 could be a potential target for oral cancer diagnosis and treatment.
Dr ArunKumar Ganesan
Read the Original
This page is a summary of: Long non-coding RNA CCAT1 is overexpressed in oral squamous cell carcinomas and predicts poor prognosis, Biomedical Reports, March 2017, Spandidos Publications,
DOI: 10.3892/br.2017.876.
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