A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

  • Aihua Hou, Tanima Bose, K. George Chandy, Louis Tong
  • Journal of Visualized Experiments, June 2017, MyJove Corporation
  • DOI: 10.3791/55592

A rat model of autoimmune dry eye has been developed.

What is it about?

This model of autoimmune dry eye can be used to evaluate drugs that target the T cells.

Why is it important?

There is no satisfactory treatment in Sjogren syndrome and other autoimmune diseases that cause dry eye. Current treatment like steroids have adverse effects such as raised intraocular pressure. Cyclosporine is not as potent as corticosteroids.

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http://dx.doi.org/10.3791/55592

The following have contributed to this page: Louis Tong