synthetic study towards a spiroterpenoid called hyperireflexolide A

What is it about?

The first approach to hyperireflexolide A, based on the synthesis of γ-lactone-fused cyclopentane, a functionalized key intermediate, is presented. γ-lactone-fused cyclopentane is involved in hydrolysis, α-allylation at C-8 and α-methylation at C-10 stereoselectively from the convex face. Then it is subjected to cross metathesis to give α,β-unsaturated ketone 11 as precursor in the total synthesis of hyperireflexolide A.

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Why is it important?

This is first synthetic study towards, a spiroterpenoid, hyperireflexolide A. This route opens the doors for more synthetic studies towards same.