What is it about?
Excessive body fat, or obesity, poses a significant global health concern. Research has highlighted the connection between gut microbiota and obesity. This study aimed to investigate whether the administration of prebiotics and probiotics significantly contributes to controlling obesity in a rat model with induced obesity through a high-fat diet (HFD).
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Why is it important?
Obesity is associated with an increased risk of several serious health conditions, including cancer, cardiovascular diseases, type 2 diabetes mellitus (T2DM), and liver diseases. The fundamental cause of obesity is an imbalance between caloric intake and energy expenditure. An imbalance in the composition of gut microbiota, known as gut dysbiosis, triggered by dietary or environmental shifts, can lead to the proliferation of pathogenic organisms. This, in turn, fosters chronic inflammation, significantly contributing to the development of chronic metabolic and intestinal disorders. Conversely, maintaining a healthy equilibrium of intestinal microbiota may serve as a preventive or alleviating function in the context of obesity and metabolic diseases.
Perspectives
Modulation of gut microbiota emerges as a pivotal factor, mediating observed improvements in metabolic health and weight regulation. The findings suggest a promising strategy for obesity management, emphasizing the interconnected role of prebiotics, probiotics, and gut microbiota in mitigating the adverse impacts of a high-fat diet on body weight and metabolic well-being.
Syeda Zain
United Medical and Dental College
Read the Original
This page is a summary of: Exploring the Anti-Obesity Effects of Prebiotics and Probiotics in Rats; An Experimental Study, Pakistan Journal of Medicine and Dentistry, January 2024, Ziauddin University,
DOI: 10.36283/pjmd13-1/005.
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